Nano photonics and its applications
Fixler's lab deals with theoretical and practical models for reconstructing the optical properties of participating media by nano photonic tools. Our theory is based on a robust generalization of the diffusion theory; Gerchberg-Saxton algorithm; dipole-dipole approximation and other methods. On the practical side we use lasers, LEDs and microscopes. Human tissue is one of the most complex optical mediums since it is nonhomogeneous. Its optical properties are unknown and vary in different tissue areas and physiological states. Because of all of the above, in vivo imaging is a difficult task. In Dror Fixler’s lab we deal with this difficulty by focusing on detection rather than imaging. We use methods which probe the tissue properties by means of the diffusion reflection profile, adding nano particles as contrast agent, the full scattering profile and its isobaric point or iterative phase multiple measurement reconstruction techniques. Furthermore, we use changes in optical parameters, such as fluorescence life time and fluorescence anisotropy to probe the biological surroundings.
The research conducted in the lab advances non-invasive optical methods for detecting and characterizing pathological conditions in biological tissues, including cancer, vascular disorders and cardiovascular diseases. By enabling robust extraction of physiological parameters in complex scattering media, these approaches have the potential to improve early diagnosis, disease monitoring, and personalized treatment guidance.
